Hydrogen has been shown to support energy production, insulin sensitivity, and mitochondrial function. Notable trials include:

• Hydrogen water improved glucose metabolism in Type 2 diabetes patients [Kajiyama et al., 2008].
• Studies in NAFLD show improved liver function and insulin sensitivity [Korovljev & Ostojic, 2019].
• Hydrogen-rich water enhanced mitochondrial markers in overweight women [Korovljev et al., 2018].

Hydrogen-rich water and gas inhalation have been studied for muscle recovery, endurance, and fatigue:

• Enhanced VO2 max and lowered lactate in athletes [Mikami et al., 2019].
• Reduced muscle soreness after strenuous training [Botek et al., 2021].
• Improved antioxidant status and faster post-exercise recovery [Sun & Sun, 2017].

Hydrogen has been explored in Alzheimer’s, stroke, Parkinson’s, and cognitive fatigue:

• Hydrogen inhalation showed neuroprotective effects post-stroke [Ono et al., 2017].
• Improved cognitive scores in MCI and elderly adults [Nishimaki et al., 2018].
• Case reports on concussion and mild TBI recovery using hydrogen therapy [Javorac et al., 2019].

Small-scale trials show that hydrogen may reduce oxidative stress and inflammation markers in RA patients:

• RA patients consuming hydrogen water showed reduced disease activity scores [Ishibashi et al., 2012].
• Hydrogen-rich saline demonstrated anti-inflammatory effects in joint tissues [Ishibashi et al., 2014].

Hydrogen is being studied for its effects on skin inflammation, aging, and healing:

• Topical hydrogen water reduced psoriasis symptoms in clinical reports [Zhu et al., 2018].
• Improved skin hydration and reduced UV damage markers [Kato et al., 2012].

Hydrogen-enriched solutions in dialysis have been shown to reduce oxidative stress and inflammation:

• Hemodialysis with hydrogen-rich dialysate improved patient outcomes [Nakayama et al., 2015].

Hydrogen water may offer protective effects during chemotherapy and radiotherapy:

• Improved liver function in colorectal cancer patients undergoing chemo [Yang et al., 2017].
• Reduced fatigue and appetite loss in radiation patients [Kang et al., 2011].

Hydrogen inhalation is being studied for immune modulation, T-cell restoration, and quality of life improvements in advanced-stage cancers.

Hydrogen selectively targets harmful ROS like hydroxyl radicals without disrupting beneficial cell signals, confirmed in human studies.

Hydrogen is being researched for use in gut health, mental well-being, cardiovascular function, pain relief, and immune support.

Water ionizers and magnesium tablets are common methods to create hydrogen water. Studies often measure ORP (oxidation reduction potential) as a biomarker for effectiveness.

Emerging research looks at slow-release hydrogen from magnesium implants to provide localized antioxidant therapy for healing and inflammation.

Expert-written reviews compile findings across hundreds of hydrogen-related studies, offering deeper insight into mechanisms and clinical applications.

Meta-analyses confirm hydrogen's promise across domains including metabolic health, inflammation, and oxidative stress—with a strong safety profile and low side effects.